Rassie Erasmus has made two changes to the South Africa side to face England in what will be a landmark Test for Tendai Mtawarira.
Former captain Chris Robshaw has been dropped from England's squad for the second Test against South Africa.
England will welcome back Joe Launchbury for the second Test with South Africa, while Brad Shields could start for the first time.
Schalk Brits retired from rugby last month, but that has not stopped Rassie Erasmus adding him to the South Africa squad.
New Zealand legend Dan Carter believes England must stick with Eddie Jones' vision as the 2019 World Cup comes into focus.
After falling 24-3 down in the first half, the Springboks rallied to beat England in a thrilling series opener in Johannesburg.
England coach Eddie Jones pinpointed a lopsided penalty count as the reason to his side's Test defeat against South Africa.
Winger Sibusiso Nkosi scored two tries as South Africa rallied from an early 24-3 deficit to defeat England in Johannesburg.
Nick Isiekwe was Eddie Jones' "project player" on tour last year, but now he is ready to start for England in Joe Launchbury's absence.
Brad Shields will be one of two England debutants against South Africa, while injury keeps Joe Launchbury out.
It is all change for South Africa, as Rassie Erasmus has selected a new XV for Saturday's game against England.
The Springboks have been dealt a blow for their Test series with England, as Bismarck du Plessis and Frans Steyn will not feature.
England's tour of South Africa is something Ben Youngs is able to put into perspective after his sister-in-law's fight against cancer.
Despite being questioned over his methods, Eddie Jones is adamant England's players train "appropriately" for Test rugby.
South Africa were beaten in bizarre circumstances by Wales on Saturday, with new coach Rassie Erasmus acknowledging the need to improve.
There was a late twist in the tale as Rassie Erasmus suffered defeat to Wales in his first match as South Africa coach.