Wales coach Warren Gatland has named Ellis Jenkins as captain for his side's clash with South Africa on Saturday.
Seven uncapped players will be given the chance to impress Rassie Erasmus when South Africa face Wales in Washington on Saturday.
Eddie Jones has been forced to bring in three replacements for the upcoming series against the Springboks.
Eddie Jones is confident England will have "opportunities" to create history in South Africa.
History will be made when Stormers flanker Siya Kolisi leads the Springboks in three home Tests against England in June.
A mammoth 43-man squad has been selected for matches against Wales and England by Springboks chief Rassie Erasmus.
Saracens finished their Premiership final win over Exeter Chiefs without Owen Farrell, but his injury was not serious.
Eddie Jones believes England can make history by winning their Test series in South Africa.
Warren Whiteley's hopes of captaining the Springboks against Wales and England have been hit by a delay in his comeback from injury.
Former New Zealand international Justin Marshall says England have shown they lack strength in depth by calling up Brad Shields.
Springboks hooker Malcolm Marx has been ruled out for six weeks due to a hamstring tear, which does not require surgery.
Former England captain and coach Martin Johnson believes Eddie Jones is worryingly short of options for the tour to South Africa.
Billy Vunipola experienced hamstring tightness in training on Wednesday, but Saracens expect him to be fit for the Premiership semi-finals.
Gloucester have announced the signing of Lions captain and South Africa back-row forward Jaco Kriel for next season.
Adriaan Strauss says he would consider an offer to return to the South Africa national team seriously.
Dylan Hartley's season is over, a concussion making him unavailable for England's tour of South Africa.