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Cheslin Kolbe starred for Toulouse against Ulster, while Exeter Chiefs got the better of Northampton Saints in the European Champions Cup.
Lyon and Toulouse were both winners in Sunday's Top 14 action, with Patricio Fernandez impressing for the former.
Bordeaux-Begles, nudged into second on Saturday, could not return to the Top 14 summit at Toulouse.
Stade Francais came into the Clasico sitting bottom of the Top 14, yet they pulled off a thrilling win in Paris as Toulouse wilted.
Bordeaux-Begles are back at the top of the Top 14 and increased their advantage over Toulon and Toulouse.
Handre Pollard missed some crucial kicks on his Montpellier debut while Top 14 leaders Lyon
Rob Baxter's Exeter Chiefs survived a late scare to defeat Sale Sharks and remain firmly on track for the Champions Cup quarter-finals.
Toulouse have hit form and made light work of Bayonne at home, while Brive defeated Stade Francais.
Scrum-half Joe Simpson scored two first-half tries but Gloucester could not contain Toulouse after the break at Kingsholm.
Clermont Auvergne suffered a derby defeat to Top 14 new boys Brive as defending champions Toulouse earned their first win of the season.
Toulouse won the Top 14 last season but they have been beaten in each of their first two matches at the start of the 2019-20 campaign.
After Toulouse beat Clermont Auvergne to win the Top 14 title for the 20th time, Ugo Mola paid tribute to his players.
Toulouse won the Top 14 final for the first time in seven years thanks to Yoann Huget's double against Clermont Auvergne.
Toulouse booked their place in a Top 14 final for the first time since 2012 after they overcame La Rochelle in Bordeaux.
Neither Bordeaux Begles nor Stade Francais can make the play-offs in the Top 14 after suffering painful defeats in the penultimate round.
Leinster remain on course to retain their European Champions Cup crown, but Garry Ringrose believes Saracens will be tough final opponents.
