Sean O'Brien, Tadhg Beirne and Rob Kearney come in for Ireland as Joe Schmidt makes three changes against Wales.
Wales, England and Ireland all head into the final weekend of the Six Nations season with a chance to secure the title.
Flanker Josh van der Flier will play no part in Ireland's attempt to deny Wales a Grand Slam this weekend.
Ireland superstar Johnny Sexton has pointed to recent big results against New Zealand and England as evidence that they can defeat Wales.
England scored eight tries in a rout, but Italy head coach Conor O'Shea said: "I wouldn't get too carried away with the scoreline."
Head coach Eddie Jones says England must look after themselves on what will be a tense final weekend of the Six Nations season.
Gregor Townsend was left to reflect on a missed opportunity after Scotland failed to derail Wales' quest for a Grand Slam.
Lewis Moody says England will be wounded from a defeat to Wales that he says should never have happened.
Scott Hastings says it is time Scotland did themselves justice when they face Six Nations leaders Wales at Murrayfield.
Josh van der Flier takes Sean O'Brien's place and Rory Best returns to captain a much-changed Ireland side against France.
Joe Cokanasiga will be unleashed from the start against Italy at Twickeham and Lewis Moody thinks the wing can make a big impact.
Eddie Jones has made five changes to the England team to take on Italy, Joe Cokanasiga and Ben Te'o among the players coming in.
A look back at the best facts and stats from Kieran Read's career, as he prepares to step down from New Zealand duty.
New Zealand head coach Steve Hansen says Kieran Read has enhanced the legacy of the All Blacks jersey in a "remarkable" career.
Cory Hill's ankle injury has given Adam Beard an opportunity to come back into the Wales starting line-up at Murrayfield.
Scott Hastings says the onus is on Greig Laidlaw and other senior Scotland players to step up when they lock horns with Wales.