Mako Vunipola could play for Saracens this weekend, but England were advised not to take any risks following the prop's trip overseas.
Saracens have clarified Mako Vunipola has not been in self-isolation and is free to play Leicester Tigers this weekend.
Experienced duo Dan Biggar and Liam Williams are on course to be fit for Wales' showdown with England at Twickenham.
Initially ruled out of the Wales Six Nations game for "medical reasons", England confirmed Mako Vunipola is in self-isolation.
England will not have Mako Vunipola back to face Wales, with the prop ruled out for the Six Nations encounter at Twickenham.
Ireland's clash with Italy in Dublin is the only Six Nations match to be postponed due to the coronavirus.
England prop Mako Vunipola features in their 34-man squad ahead of the game with Wales, with Jack Maunder called up.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
Josh Adams will miss the games against England and Scotland as he requires surgery on the ankle he injured against France.
Wales full-back Liam Williams has joined the Scarlets ahead of schedule, while Rhys Webb joined Bath ahead of a move to Ospreys.
Wales look highly unlikely to retain their Six Nations title after a loss to France, but Wayne Pivac felt they were hard done by.
France kept their Grand Slam hopes live with a famous win in Cardiff, but Romain Ntamack says they are not getting ahead of themselves.
Former France flanker Serge Betsen is looking forward to seeing Shaun Edwards' impact in evidence when Les Bleus take on Wales.
France should let their rugby do the talking in Cardiff after Wyn Jones fanned the flames this week, Serge Betsen says.
A wing injury crisis has led to Gael Fickou moving out wide against Wales, with centre Virimi Vakatawa back in the side.
Wayne Pivac has made two changes to his starting line-up to face France, Gareth Davies and Ross Moriarty getting the nod.