Prop Ryan Bower saw red but Worcester Warriors still ran in seven tries to record their first home win in the Premiership this season.
Leicester Tigers produced a storming second-half fightback but Ted Hill's late try gave Worcester Warriors a first win of the season.
Worcester Warriors were unable to complete a comeback from 18-0 down at Sale Sharks as they remain winless in the Premiership.
A year of persistent injury problems prompted England centre Ben Te'o to contemplate his future.
London Irish will make an immediate return to the Championship after Worcester Warriors eased to a crushing victory of Harlequins.
Leicester Tigers' play-off bid suffered an unexpected setback when Northampton Saints pulled off a derby double at Welford Road.
Scotland fly-half Duncan Weir has become Worcester Warriors' 10th signing for next season after agreeing terms on a one-year deal.
Saracens fell victim to a tremendous Leicester Tigers performance on Sunday, while there was a rare win for London Irish against Worcester.